Das neue Medikament SUN-627, entwickelt von Sundance Biosciences, k\u00f6nnte eine vielversprechende Behandlungsm\u00f6glichkeit f\u00fcr progressive Formen der Multiplen Sklerose (MS) sein. In einer ersten klinischen Studie (Phase I) zeigte sich, dass SUN-627 die TYK2-Signalwege im K\u00f6rper fast vollst\u00e4ndig (>90 %) hemmen kann \u2013 und das \u00fcber einen ganzen Tag hinweg. Besonders wichtig ist, dass der Wirkstoff auch in das Gehirn gelangt, wo er seine Wirkung entfalten kann. TYK2 ist ein Enzym, das das Immunsystem reguliert. Durch die Hemmung dieses Enzyms k\u00f6nnte SUN-627 chronische Entz\u00fcndungen im Gehirn reduzieren, die bei der MS-Progression eine zentrale Rolle spielen. “Wir freuen uns, SUN-627 als potenziell bahnbrechende Behandlungsmethode f\u00fcr progressive MS voranzubringen \u2013 eine Erkrankung, f\u00fcr die es bisher nur wenige Therapieoptionen gibt”, erkl\u00e4rt Andrew Yost, CEO von Sundance Biosciences. “Die bisherigen Ergebnisse aus klinischen und pr\u00e4klinischen Studien best\u00e4rken uns in unserem Vorhaben. SUN-627 ist ein hochwirksamer, selektiver und gehirng\u00e4ngiger TYK2-Hemmer, der gezielt die Neuroentz\u00fcndungen hinter der Blut-Hirn-Schranke bek\u00e4mpfen kann. Diese Entz\u00fcndungen sind ein Merkmal progressiver MS und werden von aktuellen Standardtherapien nicht ausreichend adressiert.” Die Hemmung von TYK2 im Gehirn k\u00f6nnte zudem die Aktivierung sch\u00e4dlicher Zellen und Botenstoffe reduzieren, die zu Nervensch\u00e4den und Demyelinisierung f\u00fchren. Im Februar pr\u00e4sentierte auch Roche Daten zu einem anderen Wirkstoff (Fenebrutinib) f\u00fcr MS, allerdings zielt dieser auf einen anderen Signalweg (BTK) ab.<\/p>\n","protected":false},"excerpt":{"rendered":"
Das neue Medikament SUN-627, entwickelt von Sundance Biosciences, k\u00f6nnte eine vielversprechende Behandlungsm\u00f6glichkeit f\u00fcr progressive Formen der Multiplen Sklerose (MS) sein. In einer ersten klinischen Studie (Phase I) zeigte sich, dass SUN-627 die TYK2-Signalwege im K\u00f6rper fast vollst\u00e4ndig (>90 %) hemmen kann \u2013 und das \u00fcber einen ganzen Tag hinweg. Besonders wichtig ist, dass der Wirkstoff […]<\/p>\n","protected":false},"author":0,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[489],"tags":[],"class_list":["post-3624","post","type-post","status-publish","format-standard","hentry","category-pharmazeutische-nachrichten"],"_links":{"self":[{"href":"https:\/\/schloss-apotheke-kuemmersbruck.de\/produkte\/wp-json\/wp\/v2\/posts\/3624","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/schloss-apotheke-kuemmersbruck.de\/produkte\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/schloss-apotheke-kuemmersbruck.de\/produkte\/wp-json\/wp\/v2\/types\/post"}],"replies":[{"embeddable":true,"href":"https:\/\/schloss-apotheke-kuemmersbruck.de\/produkte\/wp-json\/wp\/v2\/comments?post=3624"}],"version-history":[{"count":1,"href":"https:\/\/schloss-apotheke-kuemmersbruck.de\/produkte\/wp-json\/wp\/v2\/posts\/3624\/revisions"}],"predecessor-version":[{"id":3629,"href":"https:\/\/schloss-apotheke-kuemmersbruck.de\/produkte\/wp-json\/wp\/v2\/posts\/3624\/revisions\/3629"}],"wp:attachment":[{"href":"https:\/\/schloss-apotheke-kuemmersbruck.de\/produkte\/wp-json\/wp\/v2\/media?parent=3624"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/schloss-apotheke-kuemmersbruck.de\/produkte\/wp-json\/wp\/v2\/categories?post=3624"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/schloss-apotheke-kuemmersbruck.de\/produkte\/wp-json\/wp\/v2\/tags?post=3624"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}